The gut microbiome is an important component of the gastrointestinal tract (GIT), which possesses the largest and most susceptible surface with excellent characteristics for observing foods, nutrients, and environmental factors, as well as distinguishing commensals from invading pathogens. In the context of health and sickness, it is generally understood that the gut has a close relationship with the central nervous system (CNS). Normal brain processes and emotional behaviours require a healthy stomach with a diversified microbiome. Furthermore, the CNS is in charge of the majority of GI physiology. The intricate and bidirectional molecular relationship between the gut/microbiome and the CNS ensures gut homeostasis and correct digestion. Probiotics are live microorganisms that, when consumed in sufficient proportions, provide health advantages. The microbiota/gut-and-brain axis is a developing and widely acknowledged notion that links changes in the bidirectional interaction between the GIT and CNS with the pathophysiology of gastrointestinal and neurological illnesses.