The gut microbiome has gotten a lot of attention in the last decade, and there's been a lot of interest in probiotics and prebiotics as a way to modify the gut microbiota. Given the relevance of these approaches for public health, it's important to review the facts and evidence that support their clinical application and use. At birth, the human gut is largely vaccinated. As feeding and eating patterns mature, microbial diversity grows. The microbiota of children aged 3–5 years mimics that of adults. The gut microbiota could be at the root of many diseases, and modulating it could lead to novel and more effective treatments. So, what exactly do probiotics and prebiotics do? Both therapies, in general, aim to boost the number of beneficial microorganisms and the products of their development and metabolism in the host. Regardless of these unanswered questions, probiotics continue to attract a lot of interest from health professionals, and consumers view probiotics accessible in various formats on the market as a fresh ray of hope for managing their health care and well-being.
Title : Overcoming manufacturing challenges in next-generation probiotics: From anaerobic cultivation to clinical-grade formulation
Jason Ryan, Sacco System, Australia
Title : Treating irritable bowel syndrome patients with a balanced multi-strain synbiotic – results from a multi-center, randomized, double-blind, placebo-controlled clinical trial (the ViIBS trial)
Henning Sommermeyer, Calisia University, Poland
Title : Global regulatory trends on the use of probiotics and prebiotics in foods and food supplements
David Pineda Ereno, DPE International Consulting, Belgium