Probiotics and prebiotics have gotten a lot of attention in the scientific, healthcare, and public realms in recent years. Microbiome research has also widened the public image of microbes, moving away from disease-causing agents that should be avoided and toward a more reasonable approach that incorporates an appreciation of bacteria' beneficial roles in human health. As a result of these advancements, public awareness and acceptance of probiotics and prebiotics is growing, with probiotic industry growth predicted at 7% yearly and prebiotic growth forecast at 12.7 percent over the next eight years. New candidate probiotic strains will not just come from the gut microbiome. The female urogenital tract, mouth cavity, nasopharyngeal tract, and skin are all areas of great interest for novel species discovery and action. Emerging healthcare concerns will spur research into new areas of global health importance, and a growing body of evidence for essential applications will help policymakers and practitioners make better decisions.