Title : Identification and characterization of bacteria related to Gout
Abstract:
The global incidence of gout has continually increased to about 1%. Gout is a heterogeneous disease in which blood uric acid levels are elevated due to disorders of purine metabolism or uric acid excretion. When the blood uric acid level exceeds the joint monosodium urate saturation, urate crystals are precipitated and deposited in the peripheral joints and surrounding tissues, thus causing a local inflammatory response, resulting in a gouty attack. As an important physiological flora in the human gut, probiotics, which refer to a group of microorganisms that have beneficial effects on the host, have functions such as enhancing immunity, maintaining intestinal mucosal barrier, antibacterial and immune regulation. There are many types of probiotics, mainly including Bifidobacterium, Lactobacillus, Bacillus, Streptococcus and other types 14. About 30% of uric acid in the human body is directly excreted from the intestine or degraded by the intestinal flora. Studies have shown that some probiotics have the effect of degrading uric acid. Uric acid is the terminal metabolite of purine metabolism in humans because of the pseudogenization of the uricase gene. It is an oxidoreductase involved in the body’s purine metabolism and can convert uric acid to allantoin, whose solubility is 5 to 10 times that of uric acid, which is soluble in urine and excreted by the kidneys. Because urate oxidase can degrade uric acid rapidly and has the advantages of high specificity and sensitivity in the binding and oxidation of blood uric acid, it has been widely used in the detection of blood uric acid and in the clinical treatment of diseases caused by hyperuricemia and gout. Uric acid oxidase can be used for gout treatment, however, for a better treatment of gout it’s urgently required to identify novel uric acid oxidase and novel bacteria related to gout. Here we report a novel bacteria related to gout, which has great potential for better treatment of gout. Detailed identification and characterization of the bacteria related to gout will be described during the meeting.
