Title : Impact of gut microbiome and intestinal parasite in immune-mediated bowel disease
Abstract:
Minor parasite invasion has decreased in developed nations over the past few years. Additionally, transmissible agents can defeat autoimmune conditions and hypersensitive reactions. Irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD) are the two most common immune-mediated intestinal ailments, and a few studies have shown that a variety of protozoa and helminths are linked to these conditions. IBD, or inflammatory bowel disease, refers to inflammatory disorders of the stomach, small intestine, and colon, including ulcerative colitis and Crohn's disease. IBD's specific cause is still unknown, however, it may be related to variations in the intestine's microflora that lead to an excessive inflammatory response to commensal microbiota. Irritable bowel syndrome is essentially a long-lasting, persistent gastrointestinal illness and symptoms typically include swelling, cramps or severe pain, diarrhoea, and constipation. The immune systems of infected hosts can be affected by various intestinal parasites, and in some situations, they can change or vary the host's immunological responses, especially in autoimmune diseases like celiac disease and inflammatory bowel disease (IBD). We found that intestinal parasites and gut microbiome have a relation for causing IBD and by maintaining the gut microbiome the disease burden may be reduced.
