Title : Autoprobiotics as an alternative way to eradicate Helicobacter pylori infection
Abstract:
Aim: Evaluation of the clinical efficacy of autoprobiotic (indigenous enterococci) monotherapy in H. pylori eradication.
Materials and methods: 95 patients with H. pylori-associated dyspepsia underwent examination: assessment of symptoms of dyspepsia before and after treatment, endoscopic examination of the upper gastrointestinal tract with biopsy to verify H. pylori infection (biochemical, bacteriological, molecular genetic examination of biopsies). Antagonistic activity against H. pylori in vitro for an autoprobiotic based on indigenous Enterococcus faecium was determined by the drip method. To study the antagonistic activity in vivo, an autoprobiotic with indigenous Enterococcus faecium was used, which was prescribed per os twice a day for 50 ml (8,0 LGU/ml) for 20 days. Eradication control was made using the determination of the antigen of the microorganism in the feces 1.5-2 months after the end of treatment.
Results: Initially, H. pylori infection was confirmed in 49.4% of patients. In vitro, the sensitivity of the microorganism to indigenous enterococci was detected in 81% of the strains.
12 patients received autoprobiotic as monotherapy. This group included patients with a history of allergic reactions to antibiotics used in standard eradication therapy regimens. When using an autoprobiotic, the eradication rate was 80%. Relief of symptoms of dyspepsia (belching, heartburn, epigastric pain, nausea, flatulence) was noted in all patients.
Conclusion: The sensitivity of the studied H. pylori strains to an autoprobiotic is comparable to the sensitivity of the microorganism to antibiotics often used in eradication schemes. Monotherapy with an autoprobiotic with indigenous enterococci showed a high percentage of elimination of the pathogen. If it is impossible to use standard anti-helicobacter therapy, the appointment of autoprobiotics is a reasonable alternative treatment option. However, further research is needed to expand the evidence base for evaluating the effectiveness of enterococcal-based drugs in H. pylori eradication.
Audience Take Away:
- Colon microbiota dysbiosis is one of the important mechanisms for the development of many internal diseases. The audience will be able to know about autoprobiotics – the promising way to restore colon microbiota disorders.
- Autoprobiotics is the practical solution to a problem of Helicobacter pylori eradication, especially for patients with a history of allergic reactions to antibiotics used in standard eradication therapy regimens.
- Autoprobiotics is the personalized therapy method that is very actual to use nowadays.
