Title : Does probiotic supplementation help with gestational diabetes mellitus?
Abstract:
Background and aims
Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and related to many adverse events of pregnancy. There are previous evidences that probiotics can be regarded as a therapeutic option in GDM. In this systematic review article, the effect of probiotic supplementation in GDM has been evaluated.
Methods
A systematic search for literatures was done through PUBMED/Medline and Google Scholar up to June 2021. This systematic review followed Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) Guideline for evaluation of the effect of probiotic supplementation on gestational diabetes mellitus.
Results
The component of probiotic supplements varied in different studies. However, the most prevalent species in approximately all of studies was Lactobacillus. Probiotic supplementation can reduce the fasting plasma glucose. Furthermore, probiotics reduced risk of GDM. On the other hand there are previous RCTs that have shown no beneficial effect for probiotics supplementation on the FPG or GDM risk. The difference of result in these studies can be related to viable counts of bacteria or types of probiotic strains. Furthermore, the power of some trials is insufficient due to have a low number of participants.
Conclusion
This study suggests that probiotic supplementation is associated with the reduced risk of GDM and a significant reduction in FPG. These findings are promising that maybe probiotic supplementation is useful as a therapy in GDM. However, it looks like that more RCTs with different doses and more probiotic strains in probiotic supplements and its effects on GDM could be warranted.
