Title : Arsenic exposure and cognitive health: understanding the relationship between arsenic related neurotoxicity and role of gut microbiota
Abstract:
Gut microbiota plays a crucial role in retaining the hemostasis of host body however under the exposure of various heavy metals the composition of gut biota is disturbed in terms of species diversity and richness. Ever since the increase of microbiome related studies during the last decade, many research studies have delivered the understanding of the causes and concerns of alteration in the gut microbiota. The factor that regulates the microbiome includes nutrition and environmental pollutants that lead to alteration in the gut microbiome significantly. During the past decade research related to influence of heavy metal in gut microbiota alteration has increased and it’s been confirmed from various studies that heavy metals alters the microbial composition which result in change in gene expression, alterations in metabolism, immunity, and neurological dysfunction. Majority of the studies regarding heavy metal effects on gut microbiota has targeted the toxic metals such as lead, arsenic, cadmium and mercury and model organisms such as fish (Danio rerio and Pimephales promelas) and mice (mus musculus).
