A recent clinical (ViIBS) trial investigating the effects of a balanced multi-strain synbiotic in irritable bowel syndrome (IBS) patients showed that twelve weeks of treatment resulted in significant improvements across all major IBS symptoms. The current observational study purs [....] » Read More
Effects of a balanced multi-strain synbiotic in patients with moderate to severe Irritable Bowel Syndrome (IBS) of all stool form types were characterized in a multi-center, randomized, double blind, placebo-controlled clinical study. A total of 202 adult IBS patients were random [....] » Read More
The global market for probiotics and prebiotics continues to grow with increasing consumer demand over the years. Consumers have become more health conscious than ever. Consumer demand internationally is expected to increase further helping individuals meet their optimum health g [....] » Read More
Next-Generation Probiotics (NGPs), consisting of non-traditional commensal microorganisms with targeted health benefits, are at the forefront of microbiome-based therapeutics. Unlike conventional probiotics, NGPs such as Faecalibacterium prausnitzii, Bacteroides xylanisolvens, Al [....] » Read More
In recent decades, the role of the microbiome in the pathogenesis and therapy of chronic diseases has received increased scientific attention, particularly in the context of the "gut-brain axis" concept. However, the systematic study of the human microbiota and its cent [....] » Read More
Introduction: Biofilm in hospital environments provides the ideal environment for pathogenic bacteria to thrive. Cleaning and disinfection does not affect bacteria 'hiding' in the biofilm. By using environmentally friendly probiotic bacteria to eliminate biofilm there may [....] » Read More
Introduction: Multidrug-resistant micro-organisms are a growing concern in the United Arab Emirates (UAE), with a rate of Multi-Resistant Staphylococcus Aureus (MRSA) of up to 26,4% according to latest estimates (1). This involves the community as well the more specific populatio [....] » Read More
Transitioning probiotics from lab-scale to commercial production demands careful strategies to overcome technical, regulatory, and economic barriers. Manufacturer of probiotics face scale up challenges like media sterilization, media cost, selecting suitable media, identifying co [....] » Read More
Conventional probiotics are typically derived from a narrow spectrum of microbial species, which may inherently limit the diversity of their functional attributes and mechanisms of action. Conversely, microorganisms isolated from hosts adapted to extreme environments often exhibi [....] » Read More
Postbiotics, defined as bioactive metabolites produced by probiotics that confer health benefits, have increasingly attracted attention owing to their antioxidant, antimicrobial, and immunomodulatory properties. These attributes render them promising candidates for the prevention [....] » Read More
Recent studies have increasingly emphasized the immunomodulatory potential of Exopolysaccharides (EPS) derived from probiotic bacteria, identifying them as promising natural, biocompatible, and effective candidates for immune modulation. In the present study, we investigated the [....] » Read More
Background: Vitamin D deficiency is prevalent among young women and has been linked to immune dysregulation, metabolic disorders, and gut microbiota alterations. However, large-scale metagenomic studies examining the relationship between serum vitamin D and gut microbial composit [....] » Read More
Background: Vitamin D deficiency is prevalent among young women and has been linked to immune dysregulation, metabolic disorders, and gut microbiota alterations. However, large-scale metagenomic studies examining the relationship between serum vitamin D and gut microbial composit [....] » Read More
The gut microbiome is a complex and dynamic microbial ecosystem that plays a pivotal role in metabolic regulation, immune modulation, and neurological function across the human lifespan. Ageing is associated with marked alterations in gut microbiota composition, influencing susce [....] » Read More
Atherosclerosis, a chronic inflammatory disease of medium and large arteries, is the leading cause of myocardial infarction and cerebrovascular accidents, accounting for more global deaths than any other condition. Although lifestyle modifications and pharmacotherapies have reduc [....] » Read More
Medicinal plants are of great importance worldwide and can be used alone and as a supplement to traditional medication. The remarkable number of reports on the nutritional and therapeutic properties of medicinal plants combined with long-term experience in folk medicine has led t [....] » Read More
The increasing emphasis on sustainability in the food industry has heightened interest in converting fruit processing by-products into value-added functional ingredients. Persimmon (Diospyros kaki), a fruit with growing global production, generates significant amounts of peels an [....] » Read More
We eat vegetables that contain bacteria (1) many of which are capable of producing plant hormones such as auxins. Thus, we eat bacteria that produce auxins. Will bacteria produce auxins in our guts? If so, what are the effects of auxins in human health? Indole-acetic [....] » Read More
Ulcerative Colitis (UC) is a relapsing-remitting inflammatory disorder of the gastrointestinal tract driven by complex interactions between the gut microbiota and dysregulated mucosal immune pathways. In this study, we identify microbiota-derived succinate as a key metabolic driv [....] » Read More
The establishment of the oral microbiome begins at birth and plays a decisive role in shaping lifelong oral health. Early microbial colonizers influence immune maturation, biofilm formation, and susceptibility to dental caries and periodontal conditions. Disruption of this delica [....] » Read More
The effectiveness and action potential of probiotics depend on their adhesion to the host tissue. The effective host interactions rely heavily on their ability to aggregate and adhere to host tissues, thereby supporting mucosal colonization, immune modulation, and competitive exc [....] » Read More
Background: Functional Dyspepsia (FD) is a common disorder that is difficult to treat and has a significant negative impact on the quality of life of patients. There is growing evidence that the small intestinal microbiota plays a role in the pathophysiology of FD. Aim: To stu [....] » Read More
The human gut microbiome, comprising trillions of microorganisms, functions as a virtual endocrine organ that profoundly influences metabolic health through complex bidirectional communication with host physiological systems. Recent evidence demonstrates that dietary strategies t [....] » Read More
The rapid increase in overweight, obesity and type 2 diabetes has intensified the demand for sweet food options that provide sensory pleasure while exerting a lower glycaemic impact and offering additional physiological benefits. In this context, candied fruits reformulated with [....] » Read More
Carotenoid pigments play an important role in aquaculture due to their well-known contributions in enhancing coloration, oxidative stability, and overall fish health. Among them, astaxanthin stands out as one of the most powerful natural antioxidants described to date, exhibiting [....] » Read More
The human gastrointestinal microbiome performs an essential role in maintaining the homeostasis of the intestine by regulating host inflammation and immune responses. This important function of the gastrointestinal microbiota is affected by changes in its composition caused by li [....] » Read More
Congenital Heart Defects (CHD) remain a leading cause of morbidity and mortality in early childhood and often require surgical correction within the first months of life. Despite advances in pediatric cardiac surgery and intensive care, the early postoperative period continues to [....] » Read More
Understanding the microbial dynamics and functional potential of fermentation microbiota is crucial for optimizing product quality, ensuring food safety, and advancing the development of health-promoting functional beverages. Traditional microbiological methods and 16S rRNA seque [....] » Read More
Probiotics are increasingly studied in fish nutrition for their role in enhancing health and reducing antibiotic use. Nonetheless, the efficacy of probiotics in aquaculture diets is influenced not only by the selection of the microorganism species but also by the feed processing [....] » Read More
Background: Infants with Congenital Heart Defects (CHD) frequently experience growth failure and metabolic disturbances that cannot be fully explained by hemodynamic factors alone. Increasing evidence suggests that early-life gut microbiome dysbiosis may contribute to impaired nu [....] » Read More
Probiotics are widely used in the prevention and treatment of infectious diseases, primarily through the modulation of immune and physiological systems. This study analysed the genomic structure of Megasphaera elsdenii CH4, a probiotic strain isolated from the rumen of a Holstein [....] » Read More
