Title : The association between dietary pattern and plasma Short-Chain Fatty Acids (SCFA) level, level of gut permeability (zo-1),level of glp-1, and Homa-ir in Kajang and Makassar population
Abstract:
Background:
Ultra processed have been linked to metabolic disease however study on ultra processed food and its relationship with metabolic hormones are scarce. In this study, we seek Kajang ethnic who lives isolated and still defending their natural diet and compared with urban population’s diet represented by Makassar population. We investigated the association between dietary pattern and short-chain fatty acids (SCFA) and ZO-1, GLP-1, and HOMA-IR level in Kajang and Makassar population.
Methods:
This is a cross-sectional study with rural diet reflected by Kajang ethnic, tana toa village (n=24) and Makassar city (n=40). We included participants aged > 50 years old with no history of antibiotic/prebiotic/probiotic used within 3 months and excluded participants with history of diabetes mellitus, history of acute or chronic gastrointestinal disease, and income > 3.000.000 IDR. We obtained plasma SCFA, ZO-1, GLP-1, and HOMA-IR measurements.
Result:
Energy, energy-ultra processed food (EUPF), protein, fat, natrium, calcium intakes were higher significantly (p<0.01) in Makassar population, whereas fiber intake was higher significantly in Kajang population compared to Makassar population (p < 0.01). HOMA-IR (p < 0.01) and ZO-1 level (p < 0.05) were lower significantly in Kajang population compared to Makassar population and plasma SCFA was higher significantly in Kajang population compared to Makassar population (p < 0.01).
Conclusion:
Kajang population, characterized by higher fiber, lower fat, minimally processed foods, and lower salt intake has been shown to benefit metabolic profiles.
